Transmuting α helices and β sheets
نویسندگان
چکیده
منابع مشابه
Transmuting a helices and b sheets
Protein architecture involves two main secondary structural classes: helices and sheets. Some natural proteins alter their fold in response to changes in solution conditions or as a consequence of mutation. Here, we discuss recent attempts to induce such conformational changes by design: specifically, the motivation and success of efforts to change one protein fold into a different one in respo...
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The structures and properties of unsolvated peptides large enough to possess secondary structure have been examined by experiments and simulations. Some of the factors that stabilize unsolvated helices and sheets have been identified. The charge, in particular, plays a critical role in stabilizing a-helices and destabilizing b-sheets. Some helices are much more stable in vacuum than in aqueous ...
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Simple models are presented that describe the rules for almost all the packing that occurs between and among cu-helices and pleated sheets. These packing rules, together with the primary and secondary s tructures , are the major determinants of the three-dimensional s tructure of prote ins . Twenty-six years ago, Pauling and his colleagues (1, 2) presented the a-helix and the parallel and antip...
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Max-Planck-Institut für biophysikalische Chemie Abteilung Spektroskopie 37070 Göttingen, Germany Isotope editing of amide infrared bands not only localises secondary structural elements within the protein but also yields conformational information that is not available from the linear dichroism of aligned samples without isotope editing. The additional information that can be derived on the ori...
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We examine the role of residues of secondary structure in recognition of the native structure of proteins. The accuracy of recognition was estimated by computing the Z-score values for fragments of protein chains in threading tests. By testing different combinations of secondary structure fragments of 240 non-homologous proteins we show that the overwhelming majority of proteins can be successf...
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ژورنال
عنوان ژورنال: Folding and Design
سال: 1997
ISSN: 1359-0278
DOI: 10.1016/s1359-0278(97)00036-9